Endocrine Abstracts

Introduction: The increased risk of cancer in patients with diabetes mellitus (DM) creates an interest in finding mechanisms of the possible association of antidiabetic drugs and carcinogenesis. Metformin has the most documented evidence of pleiotropic oncoprotective effects, including increased stabilization of tumour suppressor p53, inhibition of NF-κB activation, slowing of the cell cycle and inhibition of mitosis due to decreased expression of cyclin D and cyclin E, a...

Objectives: The Clinical Activity Score (CAS) is used to measure and classify Graves orbitopathy activity (GO). However, CAS is partly subjective, and the evaluation of its components is binary. As CAS is known to be correlated with TSH receptor antibodies (TRAb), we wanted to evaluate other immunological parameters in the peripheral blood as markers of GO activity.Methods: The study included 32 patients (19 females, 13 males). CAS was evaluated by a sin...

Introduction: Severe insulinopenic diabetes (SID) is a rare complication of treatment with immune checkpoint inhibitors (ICPI). We describe herein the clinical characteristics, natural history and potential predictors of SID in cancer patients treated with ICPI.Methods: We identified and retrospectively retrieved pertinent clinical data of all patients who presented with new onset SID following treatment with ICPI between 2015 and 2022 at the Tel Aviv-So...

Introduction: Increased levels of high-sensitivity C-reactive protein (hs-CRP) and interleukin 6 (IL-6) accelerates atherosclerosis and occurrence of cardiovascular complications in patients with type 2 diabetes (T2D). Intima-media thickness (IMT) is a surrogate marker of atherosclerosis in patients with T2D.Aim: The aim of the study was to evaluate the significance of determining inflammatory markers IL-6, hs-CRP and IMT, as atherosclerosis markers, dur...

Transient neonatal diabetes mellitus (TNDM) occurs in 50-60% of all cases of neonatal diabetes mellitus (NDM). The most common cause of TNDM (70%) is almost invariably associated with defect in chromosome 6 and mutations in the KCNJ11, ABCC8, INS, NHF1B etc. genes. TNDM is caused by mutations in the GATA6 gene in rare cases. This gene encodes a transcription factor that is important for the development of the hematopoietic, cardiac and gastrointestinal systems.<p ...

We identified factors that significantly influenced the development of the X-syndrome. A significant influence on the development of X-syndrome have increase the level of total cholesterol (b=0.65; P=0.036; Exp (b) =1.92 (1.04÷3.54)). Increases the risk of X-syndrome increase the level of apo-B-protein (b=4.79; P=0.014; Exp (b) =12.69 (2.68÷54.41)). The increase in linear dimension of preperitonialy fat increased ...

Chronic hypoparathyroidism affects ~2.5/10 000 individuals in the European Union and is classified as a rare disorder. There is limited knowledge of the natural history and epidemiology of this disease. Publications frequently represent a single center’s experience and information across the population of patients with hypoparathyroidism is lacking and needed. To fill the gap, a voluntary global hypoparathyroidism patient registry (PARADIGHM) was initiated by NPS Pharmace...

Methods: 157 patients (118 women and 39 men) aged from 30 to 73 years with radical treatment for Graves’ disease were included in this study. Patients were divided into two groups depending on a type of radical treatment: 76 patients have received radioiodine therapy, 81 persons received surgical treatment. Quality of life assessment was made by SF-36 questionnaire which includes eight scales: (physical functioning (PF), role physical functioning (RPF), pain (B), general ...

Materials and methods: 157 patients (118 women and 39 men) aged from 30 to 73 years with radical treatment for Graves’ disease were included in this study. The patients were divided into two groups depending: (76) included patients with low-normal level of TSH (0.4–2.0 mU/ml), the second group (81 patients) with upper-normal level of TSH 2.1–4.0 mU/ml. Quality of life was assessed with the help of the questionnaire Short-Form SF-36.Results...

Background: Secondary hyperparathyroidism (SHPT) is an adaptive process that develops in response to declining kidney function, impaired phosphate excretion, and failure to bioactivate vitamin D. The signal transduction via the calcium-sensing receptor (CaSR) is a key determinant of parathyroid gland hyperplasia.Aims: To examine the polymorphisms rs1801725 (p.Ala986Ser, G>T), rs1042636 (p.Arg990Gly, A>G), rs1801726 (p.Glu1021Gln, G>C) of ...